A number of users are reporting an error message when they try to open any Office applications:
The operating system is not presently configured to run this application
This is apparently caused by an update to Norton security software. Either uninstall Norton or make this change:
- Open Norton's Settings, then Firewall
- Select Intrusion and Browser Protection.
- Disable Exploit Prevention.
- Create an appointment to remind you to enable Exploit Protection.
A bad Office update is also causing problems for some users. Uninstall March 28, 2017, update for Excel 2010 (KB3191855) if you have problems using Excel.