This macro shows how to remove a signature from a message using VBA when you are composing a message. While this macro won't save a lot of time as it's almost as easy just to select and delete it, you can add it to macros that do other things. Because it uses the ActiveInspector, it will work best with macros that automate replying, such as VBA Sample: Do Something When Reply is Clicked.

Sub RemoveSignature()
Dim Item As Outlook.MailItem
Set Item = Application.ActiveInspector.CurrentItem
    Dim objDoc As Word.Document
    Dim oBookmark As Word.Bookmark

    On Error Resume Next
    Set objDoc = Item.GetInspector.WordEditor
    Set oBookmark = objDoc.Bookmarks("_MailAutoSig")

    If Not oBookmark Is Nothing Then
        oBookmark.Select
        objDoc.Windows(1).Selection.Delete
    End If

Set Item = Nothing
End Sub

If you use this macro in a run a script rule, you'll need to use .Display to show the inspector and will see a flash on the screen as the message is opened, the signature removed, and then sent.

Tip: if you don't want to use a signature when a macro creates a new message, you can use item.body = "" or copy the body from a message to send without a signature.

For example, you can combine the macro with one that adds a note to the body and removes the signature:

Sub ReplywithNote()
Dim Item As Outlook.MailItem
Set Item = Application.ActiveExplorer.Selection.Item(1)

Dim olInspector As Outlook.Inspector
Dim olDocument As Word.Document
Dim olSelection As Word.Selection

Set myReply = Item.Reply
myReply.Display

Set olInspector = myReply.GetInspector
Set olDocument = olInspector.WordEditor
Set olSelection = olDocument.Application.Selection

olSelection.InsertBefore "This is my note"

Set oBookmark = olDocument.Bookmarks("_MailAutoSig")

If Not oBookmark Is Nothing Then
    oBookmark.Select
    olDocument.Windows(1).Selection.Delete
End If

' uncomment to send
 'myReply.Send

End Sub

Macro samples to insert signatures are available at

Insert or change a Signature using VBA

How to use the Macro

First: You will need macro security set to low during testing.

To check your macro security in Outlook 2010 and newer, go to File, Options, Trust Center and open Trust Center Settings, and change the Macro Settings. In Outlook 2007 and older, it’s at Tools, Macro Security. If Outlook tells you it needs to be restarted, close and reopen Outlook. Note: after you test the macro and see that it works, you can either leave macro security set to low or sign the macro.

Now open the VBA Editor by pressing Alt+F11 on your keyboard.

To put the code in a module:

1. Right click on Project1 and choose Insert > Module
2. Copy and paste the macro into the new module.

More information as well as screenshots are at How to use the VBA Editor.