Signatures are stored in the roaming section of the windows profile, under
%appdata%\microsoft\signatures. You can push sig updates into these folders using a Windows Scripting Host (WSH) script.
You can create signatures using AD data, either using a script or a utility.
Signature assignments are in the registry at HKEY_CURRENT_USER\Software\Microsoft\Office\xx.0\Common\MailSettings\ – (where xx = your version of Office). This key is in the outlook adm file under Outlook, Tools, Options, Mail Format, Signature.
Alternately, you can add disclaimers to all messages using Exchange transport rules (Exchange 2007/2010) or with utilities installed on the Exchange or SMTP server.
More Information
Sample script to create a Signature from AD information
Disclaimer & Signature Tools for Microsoft Exchange Server
How to Configure a Disclaimer (Exchange 2007)
Understanding Disclaimers (Exchange 2010)
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Last reviewed on Sep 12, 2011

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