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Cannot start Microsoft Office Outlook Error Message

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› Problems › Cannot start Microsoft Office Outlook Error Message

Last reviewed on June 2, 2025     99 Comments

Applies to: Outlook (classic), Outlook 2010, Outlook 365 (Win)

You receive this Outlook error message: "Cannot start Microsoft Outlook. Cannot open the Outlook window. The set of folders cannot be opened."

This is typically caused by one of the following issues:

  • Your data file or profile is corrupt.
  • Another application or a COM Addin, such as a sync utility or "Skype", is accessing Outlook’s data file.
  • The navigation pane is corrupt

Microsoft Office 365 business accounts that have two (or more) Microsoft Exchange accounts in the profile may see this error (and other issues, such as rules not working) when one account has delegate or full access permissions on the other account. Remove the delegated account from the profile to solve or ask the administrator to remove full access permissions from the account.

Microsoft 365 business subscribers can use the Support and Recovery Assistant to diagnose the problem.

The navigation pane is corrupt

I'm not sure what is causing the problem, but we're seeing a rash of complaints with the following error:

Cannot start Microsoft Office Outlook. Unable to open the Outlook window. Invalid XML, the view cannot be loaded.

The users run Office Diagnostics in an attempt to fix it on their own but it finds no errors.

To fix this you need to close Outlook and reopen it using the /resetnavpane switch or find and delete <profile_name>.xml and restart Outlook. Outlook will recreate a new file with the default navigation pane folders. You will lose any customizations on the navigation pane, such as folders on the Favorites folder list

This problem may occur if you are running Outlook in Compatibility mode. Compatibility mode is NOT needed with any version of Outlook on any versions of Windows (and can not be enabled on Outlook 2013 and newer).

Say No! to Compatibility Mode

 

How to use the /resetnavpane switch

  1. Close Outlook.
  2. Press Windows key + R to open the Run command.
  3. Type or paste this into the Open field: outlook.exe /resetnavpane
    Run Command
  4. Press Enter (or OK button) to restart Outlook.

Note: Make sure there is a space between outlook.exe and the switch.

Video Tutorial

[wpvideo Y9fWGzb9 w=580]

 

Delete the Navigation pane configuration file

If you are having problems using the switch, you can find and delete the XML file that holds the navigation pane settings. In the Start search or Run fields or in Windows Explorer's address bar, paste the following and press Enter:

%appdata%\Microsoft\Outlook

This will open Windows Explorer to the folder where many of Outlook configuration files are kept. Find and delete the file named for your profile with the extension XML. Note that we highly recommend using the switch instead of deleting the file directly.

More Information

I can’t start Microsoft Outlook or receive the error “Cannot start Microsoft Office Outlook. Cannot open the Outlook Window”

From Outlook-tips.net:

  • How to start Outlook in safe mode
  • Using Command lines
  • Where Are My Files?

See Error with the To-Do Bar's Task list if the error is "The operation failed. An object could not be found."

Cannot start Microsoft Office Outlook Error Message was last modified: June 2nd, 2025 by Diane Poremsky

Related Posts:

  • Error with the To-Do Bar's Task list
  • How to start Outlook in Safe Mode
  • Cannot Expand Outlook Folders: Not Enough Memory
  • How to tell which Outlook profile you're using

About Diane Poremsky

A Microsoft Outlook Most Valuable Professional (MVP) since 1999, Diane is the author of several books, including Outlook 2013 Absolute Beginners Book. She also created video training CDs and online training classes for Microsoft Outlook. You can find her helping people online in Outlook Forums as well as in the Microsoft Answers and TechNet forums.

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Zenifer
February 21, 2023 5:29 am

To resolve issues with Outlook, not opening, some users have suggested turning off Compatibility mode. Here are the steps you can follow to do this:

  1. Open File Explorer and go to the folder where you installed Office. This folder is usually located at C:\Program Files\Microsoft Office(Office version).
  2. Right-click on OUTLOOK.EXE and select "Properties" from the context menu.
  3. Switch to the "Compatibility" tab and uncheck the "Run this program in compatibility mode for" option.
  4. Click "Apply" and then "OK" to exit the window.
  5. Try launching Outlook again to see if the issue has been resolved.
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Chris de Grasse
August 20, 2020 9:26 pm

The command: "outlook.exe /resetnavpane" does nothing.

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Diane Poremsky
Author
Reply to  Chris de Grasse
August 20, 2020 11:44 pm

It should reset the navigation page to the default. If you don't use Favorites in Mail module, you may not notice a change.

Which version and build of Outlook are you using? See File, Office Account for the information. 

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Doug
November 30, 2019 1:04 pm

When I launch Outlook, it starts up but when it gets as far as processing it disappears. I have tried launching it while holding the CTRL key, that doesn't work either. I have office 365. Any suggestions would be great. Thanks for your time.

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Patrick
October 12, 2018 5:19 am

I can't even open Outlook. I get this error message;
Cannot start Microsoft Outlook. Cannot open the Outlook window. The set of folders cannot be opened. File access is denied. You do not have permission required to access the file C:\users\username\Documents\OutlookFiles\emailaddress.pst

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Toni Staton
August 16, 2016 4:23 pm

I can't get outlook to open, it say processing, help what I'm I to do

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Diane Poremsky
Author
Reply to  Toni Staton
August 17, 2016 12:32 am

Close it and restart in Safe mode - see if it opens. To open Outlook in Safe mode: Close Outlook then hold Ctrl as you click on the Outlook icon. You'll get a message asking if you want to start in Safe mode. Click Ok.

What type of email account is configured in Outlook?

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Debi Weaver
March 30, 2016 9:56 am

I ended up going to the Microsoft store. They went in and did a repair twice and finally we had to re-install using my product key. They had no explanation as to what the problem was. This is the 2nd time I have had to do this. I think there is some kind of gliche in the Microsoft 2016 software.

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barbara
November 23, 2015 1:25 pm

when trying to open outlook get message microsoft outlook has stopped working problem caused program to stop working correctly

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Rob
May 19, 2015 6:54 pm

Running Windows 8.1 and Outlook 2013
Clicking on the Outlook icon does nothing.
when trying "outlook /safe" error message returned is
c:\program files\ microsoft office 15\ root\office15\outlook.exe
The volume for a file has been externally altered so that the opened file is no longer vaild.

How do get it started again ?

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Diane Poremsky
Author
Reply to  Rob
June 28, 2015 1:11 am

You'll need to repair the office installation.

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